I. ʻIke Kumu
Inoa Generic: Semaglutide
ʻAno: GLP-1 receptor agonist (lōʻihi glucagon-like peptide-1 analog)
ʻO ka hana maʻamau o ka hoʻokele ʻana: hoʻoheheʻe ʻia ma lalo o ke kino (hoʻokahi pule i kēlā me kēia pule)
II. Nā hōʻailona a me ke kūlana ʻae ʻia i ka home
ʻApono ʻia nā hōʻailona
Lapaʻau maʻi maʻi type 2 (Apono ʻia e ka NMPA):
ʻAi: 0.5 mg a i ʻole 1.0 mg, hoʻokahi pule i kēlā me kēia pule.
Nā hana: Hoʻoponopono i ka glucose koko a hoʻemi i ka pilikia cardiovascular.
Lapaʻau Obesity/Overweight
III. Mechanism of Action and Efficacy
Mechanism Core: Hoʻoulu i nā mea loaʻa GLP-1, hoʻopaneʻe i ka hoʻokuʻu ʻana o ka ʻōpū, a hoʻonui i ka māʻona.
Ke hana nei ma ka hypothalamic appetite center, inhibiting appetite.
Hoʻonui i ka naʻau o ka insulin a hoʻoponopono i ka metabolism.
ʻO ke kaumaha o ke kaumaha (Ma muli o nā hoʻokolohua lapaʻau honua):
Awelika kaumaha kaumaha ma luna o 68 pule: 15%-20% (i hui pū me ka nohona interventions).
ʻO nā maʻi maʻi maʻi ʻole (BMI ≥ 30 a i ʻole ≥ 27 me nā pilikia):
ʻO nā poʻe maʻi maʻi diabetic: Hoʻohaʻahaʻa iki ka hopena o ke kaumaha (ma kahi o 5%-10%).
IV. Pili ka heluna kanaka a me nā Contraindications
Ka heluna kanaka pili
Nā Kūlana Kūikawā (e nānā iā WHO):
ʻO ka BMI ≥ 30 (ka momona);
ʻO BMI ≥ 27 me ke kiʻekiʻe kiʻekiʻe, ka maʻi diabetes, a i ʻole nā maʻi metabolic ʻē aʻe (ke kaumaha).
Hoʻomaʻamaʻa ʻĀina: Pono ka loiloi kauka; Hoʻohana nui ʻia i kēia manawa no ka mālama paona i nā maʻi maʻi diabetes.
Contraindications
ʻO ka moʻolelo pilikino a ʻohana paha o ka medullary thyroid carcinoma (MTC);
ʻO ka maʻi maʻi endocrine neoplasia he 2 (MEN2);
Nā wāhine hāpai a lactating paha;
ʻO nā maʻi ʻeha nui (e like me ka mōʻaukala o ka pancreatitis).
V. Nā hopena a me nā pilikia
Nā hopena ʻaoʻao maʻamau (ʻoi aku ma mua o 10%):
Nausea, luaʻi, diarrhea, constipation (hoʻemi ʻia me ka hoʻohana lōʻihi).
Hoʻemi ʻia ka ʻai, luhi.
Nā pilikia koʻikoʻi:
ʻO nā maʻi maʻi C-cell thyroid (nā pilikia i hōʻike ʻia i nā haʻawina holoholona, ʻaʻole maopopo i ke kanaka);
ʻO ka maʻi pancreatitis, ka maʻi ʻōpū;
Hypoglycemia (pono e akahele ke hoʻohana pū me nā lāʻau hypoglycemic ʻē aʻe).
VI. Hoʻohana i kēia manawa ma Kina
Loaʻa nā ala:
Lapaʻau ʻana i ka maʻi maʻi maʻi: ʻO ka ʻōlelo kuhikuhi mai kahi haukapila maʻamau.
Lapaʻau Hoʻohaʻahaʻa Weight Loss: Pono ka loiloi koʻikoʻi e ke kauka; Hiki i kekahi mau keʻena endocrinology o ke kula kiʻekiʻe ke kuhikuhi iā ia.
ʻO nā pilikia mai nā Kānāwai Kūikawā ʻole: ʻO nā lāʻau lapaʻau i kūʻai ʻia ma o nā kaha kūhelu ʻole paha he hoʻopunipuni a mālama ʻole ʻia paha, e hōʻike ana i nā pilikia palekana.
VII. Nā Manaʻo Hoʻohana
E hahai pono i ka ʻōlelo kuhikuhi a Kauka: E hoʻohana wale ma hope o ka loiloi ʻana o ke kauka i nā hōʻailona metabolic a me ka mōʻaukala olakino ʻohana.
Hoʻohui Ola Ola: Pono e hui pū ʻia ka lāʻau lapaʻau me ka mālama ʻana i ka meaʻai a me ka hoʻoikaika kino e loaʻa ai nā hopena maikaʻi loa.
Ka nānā ʻana no ka wā lōʻihi: E nānā mau i ka hana thyroid, nā enzyme pancreatic, a me ka hana o ka ate a me ke kīkī.
Ka manawa hoʻouna: Nov-03-2025