Ua hōʻike ʻia nā hopena o ke aʻo ʻana i nā kāne i loaʻa i ka testosterone undecanoate injections lōʻihi i ka mālama ʻana ma hope o ka makahiki 1 ma mua o nā kāne i loaʻa i ka pōkole testosterone propionate injections.
Ua hōʻike ʻia kahi loiloi retrospective o nā ʻikepili mai nā kāne ʻoi aku ma mua o 122,000 ma ʻAmelika Hui Pū ʻIa i nā kāne i mālama ʻia me ka testosterone undecanoate (Aveed, Endo Pharmaceuticals) i like nā helu pili i nā mahina 6 mua o ka mālama ʻana e like me nā kāne i mālama ʻia me ka testosterone cypionate.Mai ka 7 a hiki i ka 12 mahina, me 8.2% wale nō o nā maʻi i mālama ʻia me ka testosterone cypionate e hoʻomau nei i ka mālama ʻana no nā mahina 12 i hoʻohālikelike ʻia me 41.9% o nā maʻi i mālama ʻia me ka testosterone undecanoate.
"Ke hōʻike nei nā hōʻike i nā ʻano maʻalahi o ka mālama ʻana i ka testosterone, e like me ka lōʻihi o ka hana ʻana, he mea nui ia no ka makemake o nā kāne me ka testosterone deficiency e hoʻomau i ka mālama ʻana," wahi a Abraham Morgenthaler, MD, ke kaukaʻi kōkua o ke ʻoki.Ua ʻōlelo ʻo Helio ua hana ʻo ia ma ke keʻena urology ma Beth Israel Deaconess Medical Center ma Harvard Medical School."Ke ulu nei ka ʻike he ʻano olakino koʻikoʻi ka hemahema o ka testosterone a hiki i ka testosterone therapy ke hoʻomaikaʻi ʻaʻole wale i nā hōʻailona akā ʻo nā pono olakino āpau e like me ka hoʻomaikaʻi ʻana i ke kō koko koko, hoʻemi ʻia ka momona a me ka hoʻonui ʻana i ka nui o ka ʻiʻo, ke ʻano, nā iwi momona a me kahi kumu i ʻike ʻole ʻia. .anemia.Eia naʻe, hiki ke ʻike ʻia kēia mau pōmaikaʻi inā pili nā kāne i ka lāʻau lapaʻau.
Ua alakaʻi ʻo Morgenthaler a me nā hoa hana i kahi haʻawina retrospective cohort o ka ʻikepili mai ka Veradigm database, i loaʻa nā ʻikepili olakino olakino mai US outpatient hale, me ka poʻe i hoʻomaka injectable testosterone undecanoate a i ʻole testosterone cypionate ma waena o 2014 a me 2018. ʻO nā kāne 18 a ʻoi aku.ʻO ka ʻikepili i hōʻiliʻili ʻia ma nā hoʻonui 6-mahina e like me Iulai 2019. Ua wehewehe ʻia ka mālama mālama ʻana ma ke ʻano he wā ma waena o nā koho ʻaʻole i ʻoi aku ma mua o ʻelua mau manawa dosing i manaʻo ʻia no nā wiki 20 no ka testosterone undecanoate a i ʻole 4 mau pule no ka testosterone cypionate.Ua loiloi ʻia ka mālama ʻana mai ka lā o ka hoʻopaʻa ʻia ʻana a hiki i ka lā o ka hoʻopau ʻana, ka hoʻololi ʻana i ka lāʻau lapaʻau, a i ʻole ka pau ʻana o ka lāʻau testosterone i kuhikuhi mua ʻia.ʻO ka Testosterone non-adherence i ka hui testosterone undecanoate i ho'ākākaʻia ma keʻano he āpau o nā lāʻoi aku ma mua o 42 ma waena o ka lā hopena o ka koho mua a me ka lā hoʻomaka o ka kohoʻelua, aiʻole kahi āpau o nā lā ma mua o 105 ma waena o nā koho e hiki mai ana.ʻO ka piliʻole i ka hui testosterone cypionate i ho'ākākaʻia ma keʻano he wā o nā lāʻoi aku ma mua o 21 ma waena o ka hopena o kahi koho a me ka hoʻomakaʻana o ka mea aʻe.Ua loiloi nā mea noiʻi i nā loli o ke kaumaha o ke kino, BMI, ke koko, nā pae testosterone, nā helu o nā hanana cardiovascular hou, a me nā mea pilikia mai 3 mau mahina ma mua o ka hoʻokele mua ʻana i 12 mau mahina ma hope o ka hoʻomaka ʻana o ka mālama ʻana.
ʻO ka hui noiʻi he 948 mau kāne e lawe ana i ka testosterone undecanoate a me 121,852 mau kāne e lawe ana i ka testosterone cypionate.Ma ka papa kuhikuhi, 18.9% o nā kāne i ka hui testosterone undecanoate a me 41.2% o nā kāne i ka hui testosterone cypionate ʻaʻole i loaʻa kahi hōʻailona o ka hypogonadism.ʻOi aku ka kiʻekiʻe o ka testosterone manuahi ma ka baseline i nā maʻi e lawe ana i ka testosterone undecanoate i hoʻohālikelike ʻia me ka poʻe e lawe ana i ka testosterone cypionate (65.2 pg/mL vs 38.8 pg/mL; P <0.001).
I loko o nā mahina 6 mua, ua like ka nui o ka mālama ʻana i nā hui ʻelua.Ma kahi o 7 a 12 mau mahina, ʻoi aku ka kiʻekiʻe o ka hui testosterone undecanoate ma mua o ka hui testosterone cypionate (82% vs 40.8%; P <0.001).Hoʻohālikelike ʻia i nā mahina 12, ʻoi aku ka nui o nā kāne i ka hui testosterone undecanoate i hoʻomau i ka naive testosterone therapy (41.9% vs 0.89.9%; P <0.001).Nā kāne e lawe ana i ka testosterone cypionate.
"He mea kupanaha,ʻo 8.2 wale nō ka nui o nā kāne i hoʻokomo i ka testosterone cypionate i hoʻomau i ka mālamaʻana ma hope o 1 makahiki," wahi a Morgenthaler."ʻO ka haʻahaʻa haʻahaʻa loa o ka testosterone therapy maʻamau i hoʻohana ʻia ma ʻAmelika Hui Pū ʻIa, ʻo ia ka mea e hoʻomaʻamaʻa ʻia nā kāne testosterone-deficient."
ʻO ka poʻe maʻi i mālama ʻia me ka testosterone undecanoate he nui nā loli i ka nui o ka testosterone (171.7 ng / dl vs 59.6 ng / dl; P <0.001) a me ka testosterone manuahi (25.4 pg / ml vs 3.7 pg / ml; P = 0.001).ʻO ka hoʻonui o 12 mau mahina i hoʻohālikelike ʻia me nā maʻi i mālama ʻia me ka testosterone cypionate.Ua hōʻike ka Testosterone undecanoate i ka liʻiliʻi o ka nui o ka testosterone ma mua o ka testosterone cypionate.
Ma nā mahina 12, ua like nā loli o ke kaumaha, BMI, a me ke koko ma waena o nā hui.ʻO ka pūʻulu testosterone undecanoate ka hapa nui o nā kāne i ʻike hou ʻia erectile dysfunction a me ka momona i ka hahai ʻana, ʻoiai ʻo ka testosterone cypionate pūʻulu i ʻoi aku ka nui o nā kāne i loaʻa i ka hypertension, congestive heart failure, a me ka ʻeha mau.
Pono ka noiʻi hou aʻe e hoʻomaopopo i ke kumu o ka hapa nui o nā kāne i hoʻopaʻa i ka testosterone cypionate i ka mālama ʻana i loko o hoʻokahi makahiki, wahi a Morgenthaler.
"Hiki iā mākou ke manaʻo i loko o kēia haʻawina, ua hoʻohana ʻia ka testosterone undecanoate i nā helu kiʻekiʻe loa no 12 mau mahina ma muli o ka ʻoluʻolu o ka lāʻau lōʻihi, akā e ʻike inā hiki paha kēia i nā kumu ʻē aʻe (e like me ke kumukūʻai), aversion ka hoʻomaʻamaʻa pinepine ʻana iā ia iho, ka nele o ka hoʻomaikaʻi nui ʻana i nā hōʻailona, a i ʻole nā kumu ʻē aʻe, "wahi a Morgenthaler.
Ka manawa hoʻouna: Jul-05-2023